Are new neurons born in the adult human brain? Study revives debate
A new study published in Science by researchers at the Karolinska Institutet in Stockholm has provided fresh evidence for adult neurogenesis—the birth of new neurons in the adult human brain. Using single nuclei RNA sequencing and machine learning, the team analyzed over 400,000 neurons from post-mortem hippocampal samples of individuals aged under one year to 78 years. They found neural progenitor cells and young neurons in the hippocampus, the brain's memory center. This reignites a long-standing scientific debate, as previous studies have been conflicting: some suggested neurogenesis stops after infancy, while others found evidence in adults. The findings have important implications for regenerative therapies for neurodegenerative diseases like Alzheimer's and Parkinson's. Experts from CSIR-Indian Institute of Chemical Biology, University of Copenhagen, and National Centre for Biological Sciences commented on the study's significance and the historical context of the debate.
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Are new neurons born in the adult human brain? Study revives debate
A new study published in Science by researchers at the Karolinska Institutet in Stockholm has provided fresh evidence for adult neurogenesis—the birth of new neurons in the adult human brain. Using single nuclei RNA sequencing and machine learning, the team analyzed over 400,000 neurons from post-mortem hippocampal samples of individuals aged under one year to 78 years. They found neural progenitor cells and young neurons in the hippocampus, the brain's memory center. This reignites a long-standing scientific debate, as previous studies have been conflicting: some suggested neurogenesis stops after infancy, while others found evidence in adults. The findings have important implications for regenerative therapies for neurodegenerative diseases like Alzheimer's and Parkinson's. Experts from CSIR-Indian Institute of Chemical Biology, University of Copenhagen, and National Centre for Biological Sciences commented on the study's significance and the historical context of the debate.