New Brain Atlases Capture Development in Motion Across Species
A series of papers published in Nature on November 5, led by the Allen Institute for Brain Science and partners across the US BRAIN Initiative, presents groundbreaking brain atlases that map how neurons and glia form, migrate, and specialize across time and species (mouse, marmoset, human). Unlike previous static maps, these atlases show brain development as a dynamic continuum, with cells transitioning gradually through intermediate stages rather than jumping between fixed categories. Key studies by Hongkui Zeng and Tomasz Nowakowski used standardized protocols, viral barcoding, and single-cell RNA sequencing to trace cell lineages and gene activity shifts. The work provides a unified reference for developmental neuroscience, potentially guiding future research into brain circuitry and disorders.
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