New Brain Atlases Capture Development in Motion Across Species
A series of papers published in Nature on November 5, led by researchers at the Allen Institute for Brain Science and partners across the US BRAIN Initiative, have created groundbreaking brain atlases that trace how neurons and glia form, migrate, and specialize across time and species, from mouse to human. Unlike previous static maps, these new atlases portray brain development as a dynamic continuum, showing that developing cells pass through gradual transitions rather than fixed categories. Key studies include Hongkui Zeng's work on mouse brain maturation and Tomasz Nowakowski's human lineage atlas using viral barcoding to trace cell lineages in cultured human fetal brain tissue. The teams standardized protocols and built shared computational pipelines to align data, providing a unified reference for developmental neuroscience.
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