Less Invasive cTIF Procedure Shows Similar GERD Results to Gold Standard Surgery with Fewer Side Effects
A prospective randomized study presented at Digestive Disease Week indicates that consecutive transoral incisionless fundoplication (cTIF) offers a less invasive treatment option for gastroesophageal reflux disease (GERD) with outcomes comparable to the gold-standard laparoscopic Nissen fundoplication (LNF). The research, led by Dr. Barham K. Abu Dayyeh of Cedars Sinai Medical Center, involved 132 patients across seven U.S. centers. Results showed similar improvements in symptom scores and quality of life between the two groups at six and twelve months. However, patients undergoing cTIF experienced significantly lower rates of dysphagia, a common side effect of LNF, with incidence rates of 5.7% versus 28.6% at one year. While LNF remains the standard, its technical complexity and side effects limit widespread adoption. cTIF combines laparoscopic hernia repair with endoscopic valve reconstruction, potentially offering a more scalable solution for the millions of GERD patients who do not respond adequately to proton pump inhibitors. Experts note that while these short-term results are promising, further long-term studies are needed to validate the durability of cTIF benefits and establish appropriate patient selection criteria.
Wire timeline
Less Invasive cTIF Procedure Shows Similar GERD Results to Gold Standard Surgery with Fewer Side Effects
A prospective randomized study presented at Digestive Disease Week indicates that consecutive transoral incisionless fundoplication (cTIF) offers a less invasive treatment option for gastroesophageal reflux disease (GERD) with outcomes comparable to the gold-standard laparoscopic Nissen fundoplication (LNF). The research, led by Dr. Barham K. Abu Dayyeh of Cedars Sinai Medical Center, involved 132 patients across seven U.S. centers. Results showed similar improvements in symptom scores and quality of life between the two groups at six and twelve months. However, patients undergoing cTIF experienced significantly lower rates of dysphagia, a common side effect of LNF, with incidence rates of 5.7% versus 28.6% at one year. While LNF remains the standard, its technical complexity and side effects limit widespread adoption. cTIF combines laparoscopic hernia repair with endoscopic valve reconstruction, potentially offering a more scalable solution for the millions of GERD patients who do not respond adequately to proton pump inhibitors. Experts note that while these short-term results are promising, further long-term studies are needed to validate the durability of cTIF benefits and establish appropriate patient selection criteria.
MedPageToday.com - medical news for physicians